രസതന്ത്രത്തിനുള്ള നൊബേല്‍ സമ്മാനം 2014

രസതന്ത്രത്തിനുള്ള ഈ വര്‍ഷത്തെ നൊബേല്‍ സമ്മാനം മൂന്നു പേര്‍ പങ്കിട്ടു. അമേരിക്കന്‍ ഗവേഷകരായ എറിറ്റ് ബെറ്റ്‌സിഗ്, വില്യം ഇ. മേര്‍ണര്‍, ജര്‍മന്‍ ഗവേഷകന്‍ സ്‌റ്റെഫാന്‍ ഹെല്‍ എന്നിവര്‍ക്കാണ് പുരസ്‌ക്കാരം. സൂക്ഷ്മ ദര്‍ശനികളുടെ പ്രവര്‍ത്തനം മെച്ചപ്പെടുത്തുന്ന ഫ്ലൂറസെന്‍സ് മൈക്രോസ്‌കോപ്പിയുടെ കണ്ടുപിടുത്തത്തിനാണ് പുരസ്‌ക്കാരം.

CONGRATULATIONS......

Surpassing the limitations of the light microscope

ഫ്ലൂറസെന്‍സ് മൈക്രോസ്‌കോപ്പിയെക്കുറിച്ച്

        For a long time optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light. Helped by fluorescent molecules the Nobel Laureates in Chemistry 2014 ingeniously circumvented this limitation. Their ground-breaking work has brought optical microscopy into the nanodimension.

        In what has become known as nanoscopy, scientists visualize the pathways of individual molecules inside living cells. They can see how molecules create synapses between nerve cells in the brain; they can track proteins involved in Parkinson’s, Alzheimer’s and Huntington’s diseases as they aggregate; they follow individual proteins in fertilized eggs as these divide into embryos.
       It was all but obvious that scientists should ever be able to study living cells in the tiniest molecular detail. In 1873, the microscopist Ernst Abbe stipulated a physical limit for the maximum resolution of traditional optical microscopy: it could never become better than 0.2 micrometres. Eric Betzig, Stefan W. Hell and William E. Moerner are awarded the Nobel Prize in Chemistry 2014 for having bypassed this limit. Due to their achievements the optical microscope can now peer into the nanoworld.

       Two separate principles are rewarded. One enables the method stimulated emission depletion (STED) microscopy, developed by Stefan Hell in 2000. Two laser beams are utilized; one stimulates fluorescent molecules to glow, another cancels out all fluorescence except for that in a nanometre-sized volume. Scanning over the sample, nanometre for nanometre, yields an image with a resolution better than Abbe’s stipulated limit.

        Eric Betzig and William Moerner, working separately, laid the foundation for the second method, single-molecule microscopy. The method relies upon the possibility to turn the fluorescence of individual molecules on and off. Scientists image the same area multiple times, letting just a few interspersed molecules glow each time. Superimposing these images yields a dense super-image resolved at the nanolevel. In 2006 Eric Betzig utilized this method for the first time.

Today, nanoscopy is used world-wide and new knowledge of greatest benefit to mankind is produced on a daily basis. 

SCIENCE CLUB GHSS KOTTODI